This 2-part 3B MICROanatomy Liver model shows a highly magnified diagrammatic view of a section of the liver. The 3B MICROanatomy Liver illustrates the structure of the functional and structural components of the liver in two different enlargements. The left part of the model shows a section of the liver that comprises several liver lobules. The right part of the model is a highly magnified view of the sectioned liver lobule on the left. The left part and right part of the 3B MICROanatomy Liver are magnified 60-times and 200-times respectively.
Liver histology (2:50 Minutes)
Okay, let’s take a look at this liver, microscopic model. It has 2 different parts to it. You notice on the left hand side, there is a blow up of what we’ve referred to as the lobules of the liver and then on the right hand side, we have the more microscopic view. Let’s take a start to look over here. First of all, each of these roughly 6-sided structures here as referred to as a liver lobule. Right in the center of the lobule, you have what’s referred to as the central vein. You’ll notice where these 3 lobules go together, we have 3 structures at the junction of each of this lobules. Okay? Here’s another one. This is referred to as the hepatic portal triad and hepatic portal triad contains 3 different things. The red structure is a branch of your hepatic artery. The green structure is a bile canaliculus or little bile canal and the purple structure is a branch of the hepatic portal vein. What happens, this liver has 2 blood sources. It has oxygenated blood, that’s coming from the hepatic artery which ultimately comes off with the celiac trunk and you’ve got deoxygenated but nutrient rich blood that comes in through you hepatic portal vein, so the oxygen and nutrients that are coming in from the dual supply are going to take their nutrients towards the central vein. Along the way, the liver takes the nutrients that it needs, the oxygen that it needs, and so forth and whatever leftover for the body goes in that central vein which ultimately is going to lead to the hepatic vein which then goes to inferior vena cava. At the same time, one of the metabolic functions of the liver is to make bile so as these hepatocytes and this lobule make bile, bile flows on the opposite direction to blood, drains into the bile canaliculus and then ultimately, is going to exit in the liver out the hepatic ducts. So if we come over here and look at this on a microscopic view, now I’ve got each one of these cells here, we refer to as a hepatocyte. These openings, these kind of blue openings here, you can see one that’s not cut, those are your sinusoids. The liver has special capillaries we call them sinusoidal capillaries because we want to slow down blood flow and allow the liver to work, have time accessed the nutrients and so forth that are delivered to the portal circulation. Scattered throughout here we have this little kind of pinkish cells. These little pink cells are referred to as kupffer cells and those are phagocytic cells that are found in the liver and then again here on the corner, you see the part of portal triad with a bile canaliculus, the portal vein, and the their branch of the hepatic arteriole at this point. There is a good quick overview of our liver model.
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